Simvastatin Inhibits Endotoxin-Induced Apoptosis in Liver and Spleen Through Up-Regulation of Survivin/NF-κB/p65 Expression

• Main Authors: Lana Nežić (Author), Ljiljana Amidžić (Author), Ranko Škrbić (Author), Radoslav Gajanin (Author), Eugenie Nepovimova (Author), Martin Vališ (Author), Kamil Kuča (Author), Vesna Jaćević (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endotoxemia is associated by dysregulated apoptosis of immune and non-immune cells. We investigated whether simvastatin has anti-apoptotic effects, and induces hepatocytes and lymphocytes survival signaling in endotoxin-induced liver and spleen injuries. Wistar rats were divided into the groups pret...