Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators

• Main Authors: Gert de Wilde (Author), Maarten Gees (Author), Sara Musch (Author), Katleen Verdonck (Author), Mia Jans (Author), Anne-Sophie Wesse (Author), Ashvani K. Singh (Author), Tzyh-Chang Hwang (Author), Thierry Christophe (Author), Mathieu Pizzonero (Author), Steven Van der Plas (Author), Nicolas Desroy (Author), Marlon Cowart (Author), Pieter Stouten (Author), Luc Nelles (Author), Katja Conrath (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The deletion of phenylalanine at position 508 (F508del) in cystic fibrosis transmembrane conductance regulator (CFTR) causes a severe defect in folding and trafficking of the chloride channel resulting in its absence at the plasma membrane of epithelial cells leading to cystic fibrosis. Progress in...