The Impact of Acetyl-CoA and Aspartate Shortages on the <i>N</i>-Acetylaspartate Level in Different Models of Cholinergic Neurons

• Principais autores: Marlena Zyśk (Autor), Monika Sakowicz-Burkiewicz (Autor), Piotr Pikul (Autor), Robert Kowalski (Autor), Anna Michno (Autor), Tadeusz Pawełczyk (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2020-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

<i>N</i>-acetylaspartate is produced by neuronal aspartate N-acetyltransferase (NAT8L) from acetyl-CoA and aspartate. In cholinergic neurons, acetyl-CoA is also utilized in the mitochondrial tricarboxylic acid cycle and in acetylcholine production pathways. While aspartate has to be shar...