The Impact of Acetyl-CoA and Aspartate Shortages on the <i>N</i>-Acetylaspartate Level in Different Models of Cholinergic Neurons

• Main Authors: Marlena Zyśk (Author), Monika Sakowicz-Burkiewicz (Author), Piotr Pikul (Author), Robert Kowalski (Author), Anna Michno (Author), Tadeusz Pawełczyk (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<i>N</i>-acetylaspartate is produced by neuronal aspartate N-acetyltransferase (NAT8L) from acetyl-CoA and aspartate. In cholinergic neurons, acetyl-CoA is also utilized in the mitochondrial tricarboxylic acid cycle and in acetylcholine production pathways. While aspartate has to be shar...