Association of IL18 gene polymorphisms (positions -656 G/T, -137 G/C and +105A/C) with Kala-Azar

• Main Authors: Yaser Mansoori (Author), Ali Moravej (Author), Sohrab Najafipour (Author), Seyed Amin Kouhpayeh (Author), Mohammad Hasan Meshkibaf (Author), Abbas Abdollahi (Author), Manochehr Rasouli (Author), Ghader Allahverdi (Author)
• Format: Book
• Published: Fasa University of Medical Sciences, 2012-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background & Objective: Host resistance to Leishmania infection is mediated by cellular immune responses leading to macrophage activation and parasite killing. IL-18 known as interferon-γ inducing factor, stimulate IFN-γ production by T-cells. According to the important role of IL-18 in defense...