Antibody association in solution: cluster distributions and mechanisms

• Main Authors: Sandi Brudar (Author), Leonid Breydo (Author), Elisha Chung (Author), Ken A. Dill (Author), Nasim Ehterami (Author), Ketan Phadnis (Author), Samir Senapati (Author), Mohammed Shameem (Author), Xiaolin Tang (Author), Muhammmad Tayyab (Author), Barbara Hribar-Lee (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTUnderstanding factors that affect the clustering and association of antibodies molecules in solution is critical to their development as therapeutics. For 19 different monoclonal antibody (mAb) solutions, we measured the viscosities, the second virial coefficients, the Kirkwood-Buff integral...