Emerging Three-Dimensional Hepatic Models in Relation to Traditional Two-Dimensional In Vitro Assays for Evaluating Drug Metabolism and Hepatoxicity

• Main Authors: Erin Milner (Author), Michael Ainsworth (Author), Matthew McDonough (Author), Benjamin Stevens (Author), Johannah Buehrer (Author), Richard Delzell (Author), Cameron Wilson (Author), Jason Barnhill (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A vital aspect of preclinical drug development involves assessing hepatic metabolism and toxicity. These screenings are typically conducted utilizing in vitro assays and in vivo animal models; however, recent advancements in tissue engineering offer a hybrid approach to augment current protocols. Th...