Effect of formulation variables on in vitro release of a water-soluble drug from chitosan-sodium alginate matrix tablets

• Main Authors: Liang Li (Author), Jinfeng Li (Author), Shanshan Si (Author), Linlin Wang (Author), Chenjun Shi (Author), Yujiao Sun (Author), Zhenglin Liang (Author), Shirui Mao (Author)
• Format: Book
• Published: Elsevier, 2015-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The objective of this study is to investigate the feasibility of using chitosan-sodium alginate (CS-SA) based matrix tablets for extended-release of highly water-soluble drugs by changing formulation variables. Using trimetazidine hydrochloride (TH) as a water-soluble model drug, influence of dissol...