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In Vitro Activity of Sulbactam-Durlobactam against Carbapenem-Resistant <i>Acinetobacter baumannii</i> Clinical Isolates: A Multicentre Report from Italy

In the present study, the in vitro activity of the sulbactam-durlobactam (SUL-DUR) combination was evaluated against 141 carbapenem-resistant <i>A. baumannii</i> (CR<i>Ab</i>) clinical strains collected from six Italian laboratories. Over half (54.6%) of these isolates were r...

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Main Authors: Bernardetta Segatore (Author), Alessandra Piccirilli (Author), Sabrina Cherubini (Author), Luigi Principe (Author), Giovanni Alloggia (Author), Maria Lina Mezzatesta (Author), Mario Salmeri (Author), Stefano Di Bella (Author), Roberta Migliavacca (Author), Aurora Piazza (Author), Elisa Meroni (Author), Paolo Fazii (Author), Daniela Visaggio (Author), Paolo Visca (Author), Venere Cortazzo (Author), Giulia De Angelis (Author), Arianna Pompilio (Author), Mariagrazia Perilli (Author)
Format: Book
Published: MDPI AG, 2022-08-01T00:00:00Z.
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Summary:In the present study, the in vitro activity of the sulbactam-durlobactam (SUL-DUR) combination was evaluated against 141 carbapenem-resistant <i>A. baumannii</i> (CR<i>Ab</i>) clinical strains collected from six Italian laboratories. Over half (54.6%) of these isolates were resistant to colistin. The SUL-DUR combination was active against these CR<i>Ab</i> isolates with MIC<sub>50</sub> and MIC<sub>90</sub> values of 0.5 mg/L and 4 mg/L, respectively. Only eleven isolates were resistant to SUL-DUR with MIC values ranging from 8 to 128 mg/L. The SUL-DUR resistant <i>A. baumannii</i> exhibited several antimicrobial resistance genes (ARGs) such as <i>bla</i><sub>OXA-20</sub>, <i>bla</i><sub>OXA-58</sub>, <i>bla</i><sub>OXA-66</sub>, <i>bla</i><sub>ADC-25</sub>, <i>aac(6')-Ib3</i> and <i>aac(6')-Ib-cr</i> and mutations in <i>gyr</i>A (S81L) and <i>par</i>C (V104I, D105E). However, in these isolates, mutations Q488K and Y528H were found in PBP3. Different determinants were also identified in these CR<i>Ab</i> isolates, including <i>adeABC</i>, <i>adeFGH</i>, <i>adeIJK</i>, <i>abeS</i>, <i>abaQ</i> and <i>abaR</i>, which encode multidrug efflux pumps associated with resistance to multiple antibacterial agents. This is the first report on the antimicrobial activity of SUL-DUR against carbapenem-resistant <i>A. baumannii</i> isolates selected from multiple regions in Italy.
Item Description:10.3390/antibiotics11081136
2079-6382

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