Binding Parameters of [¹¹C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents

• Main Authors: Avinash H. Bansode (Author), Bhuvanachandra Bhoopal (Author), Krishna Kumar Gollapelli (Author), Naresh Damuka (Author), Ivan Krizan (Author), Mack Miller (Author), Suzanne Craft (Author), Akiva Mintz (Author), Kiran Kumar Solingapuram Sai (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Impairment and/or destabilization of neuronal microtubules (MTs) resulting from hyper-phosphorylation of the tau proteins is implicated in many pathologies, including Alzheimer's disease (AD), Parkinson's disease and other neurological disorders. Increasing scientific evidence indicates th...