A Cell-Free Screen for Bacterial Membrane Disruptors Identifies Mefloquine as a Novel Antibiotic Adjuvant

• 主要な著者: Jessica Podoll (著者), Justin Olson (著者), Wei Wang (著者), Xiang Wang (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2021-03-01T00:00:00Z.
• 主題: article
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Antibacterial discovery efforts have lagged far behind the need for new antibiotics. An approach that has gained popularity recently is targeting bacterial phospholipid membranes. We leveraged the differences between bacterial and mammalian phospholipid compositions to develop a high-throughput scre...