HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling

• Main Authors: Karolina Pytka (Author), Monika Głuch-Lutwin (Author), Elżbieta Żmudzka (Author), Kinga Sałaciak (Author), Agata Siwek (Author), Katarzyna Niemczyk (Author), Maria Walczak (Author), Magdalena Smolik (Author), Adrian Olczyk (Author), Adam Gałuszka (Author), Jarosław Śmieja (Author), Barbara Filipek (Author), Jacek Sapa (Author), Marcin Kołaczkowski (Author), Katarzyna Pańczyk (Author), Anna Waszkielewicz (Author), Henryk Marona (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Numerous studies have proven that both stimulation and blockade of 5-HT1A and the blockade of 5-HT7 receptors might cause the anxiolytic-like effects. Biased agonists selectively activate specific signaling pathways. Therefore, they might offer novel treatment strategies. In this study, we investiga...