Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris

• Main Authors: Aneese A. Jaffa (Author), Miran A. Jaffa (Author), Mayssam Moussa (Author), Ibrahim A. Ahmed (Author), Mia Karam (Author), Kawthar Sharaf Aldeen (Author), Rola Al Sayegh (Author), Ghewa A. El-Achkar (Author), Leila Nasrallah (Author), Yara Yehya (Author), Aida Habib (Author), Fuad N. Ziyadeh (Author), Ali H. Eid (Author), Firas H. Kobeissy (Author), Ayad A. Jaffa (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microglia, the resident phagocytes of the central nervous system and one of the key modulators of the innate immune system, have been shown to play a major role in brain insults. Upon activation in response to neuroinflammation, microglia promote the release of inflammatory mediators as well as prom...