When Bioequivalence in Healthy Volunteers May not Translate to Bioequivalence in Patients: Differential Effects of Increased Gastric pH on the Pharmacokinetics of Levothyroxine Capsules and Tablets

• मुख्य लेखकों: Corinne Seng Yue (लेखक), Salvatore Benvenga (लेखक), Claudia Scarsi (लेखक), Luca Loprete (लेखक), Murray Ducharme (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2015-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Purpose:  Clinical studies have suggested that proton pump inhibitors may decrease levothyroxine absorption and an in vitro study suggested that the effect of pH on dissolution may differ with formulation. To determine the impact of formulation on the pharmacokinetics of levothyroxine in altered gas...