Development of gene silencer pyrrole-imidazole polyamides targeting GSK3β for treatment of polycystic kidney diseases

Development of gene silencer pyrrole-imidazole polyamides targeting GSK3β for treatment of polycystic kidney diseases

The cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB)-glycogen synthase kinase 3β (GSK3β) signaling pathway was reported to be involved in the progression of autosomal dominant polycystic kidney diseases (ADPKD). We designed and synthesized pyrrole-imidazole (PI) polyamid...

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Main Authors: Seishiro Baba (Author), Noboru Fukuda (Author), Hiroki Kobayashi (Author), Akiko Tsunemi (Author), Yurie Akiya (Author), Taro Matsumoto (Author), Masanori Abe (Author)
Format: Book
Published: Elsevier, 2023-03-01T00:00:00Z.
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