Exome Sequence Data of Eight SLC Transporters Reveal That <i>SLC22A1</i> and <i>SLC22A3</i> Variants Alter Metformin Pharmacokinetics and Glycemic Control

• Main Authors: Monserrat I. Morales-Rivera (Author), Radamés Alemón-Medina (Author), Angélica Martínez-Hernández (Author), Cecilia Contreras-Cubas (Author), Nelly F. Altamirano-Bustamante (Author), Josefina Gómez-Garduño (Author), Elvia C. Mendoza-Caamal (Author), J. Orlando Nuñez-González (Author), Raquel García-Álvarez (Author), Cristina Revilla-Monsalve (Author), José Antonio Valcarcel-Gamiño (Author), José Rafael Villafan-Bernal (Author), Federico Centeno-Cruz (Author), Humberto García-Ortiz (Author), Francisco Barajas-Olmos (Author), Lorena Orozco (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background</b>: Type 2 diabetes (T2D) is one of the leading causes of mortality and is a public health challenge worldwide. Metformin is the first-choice treatment for T2D; its pharmacokinetics (PK) is facilitated by members of the solute carrier (SLC) superfamily of transporters, it...