High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease

• Main Authors: Christopher S. Krumm (Author), Renée S. Landzberg (Author), Lavoisier Ramos-Espiritu (Author), Carolina Adura (Author), Xu Liu (Author), Mariana Acuna (Author), Yang Xie (Author), Xu Xu (Author), Matthew C. Tillman (Author), Yingxia Li (Author), J. Fraser Glickman (Author), Eric A. Ortlund (Author), John D. Ginn (Author), David E. Cohen (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Thioesterase superfamily member 1 (Them1) is a long chain acyl-CoA thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to a C-terminal lipid-sensing steroidogenic acute regulatory transfer-related (START) domain, which allosterically modulates enzymatic activity. T...