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High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease

Objective: Thioesterase superfamily member 1 (Them1) is a long chain acyl-CoA thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to a C-terminal lipid-sensing steroidogenic acute regulatory transfer-related (START) domain, which allosterically modulates enzymatic activity. T...

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Main Authors: Christopher S. Krumm (Author), Renée S. Landzberg (Author), Lavoisier Ramos-Espiritu (Author), Carolina Adura (Author), Xu Liu (Author), Mariana Acuna (Author), Yang Xie (Author), Xu Xu (Author), Matthew C. Tillman (Author), Yingxia Li (Author), J. Fraser Glickman (Author), Eric A. Ortlund (Author), John D. Ginn (Author), David E. Cohen (Author)
Format: Book
Published: Elsevier, 2023-12-01T00:00:00Z.
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