Optimization of Ultrasound-mediated Anti-angiogenic Cancer Gene Therapy

• Main Authors: Hiroko Fujii (Author), Pratiek Matkar (Author), Christine Liao (Author), Dmitriy Rudenko (Author), Paul JH Lee (Author), Michael A Kuliszewski (Author), Gerald J Prud'homme (Author), Howard Leong-Poi (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ultrasound-targeted microbubble destruction (UTMD) can be used to deliver silencing gene therapy to tumors. We hypothesized that UTMD would be effective in suppressing angiogenesis within tumors, and that modulation of the ultrasound pulsing intervals (PI) during UTMD would affect the magnitude of t...