Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery

• Main Authors: Tarik Zahr (Author), Vijay K. Boda (Author), Jian Ge (Author), Lexiang Yu (Author), Zhongzhi Wu (Author), Jianwen Que (Author), Wei Li (Author), Li Qiang (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Estrogen is imperative to mammalian reproductivity, metabolism, and aging. However, the hormone activating estrogen receptor (ERs) α can cause major safety concerns due to the enrichment of ERα in female tissues and certain malignancies. In contrast, ERβ is more broadly expressed in metabolic tissue...