Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery

• Egile Nagusiak: Tarik Zahr (Egilea), Vijay K. Boda (Egilea), Jian Ge (Egilea), Lexiang Yu (Egilea), Zhongzhi Wu (Egilea), Jianwen Que (Egilea), Wei Li (Egilea), Li Qiang (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2024-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Estrogen is imperative to mammalian reproductivity, metabolism, and aging. However, the hormone activating estrogen receptor (ERs) α can cause major safety concerns due to the enrichment of ERα in female tissues and certain malignancies. In contrast, ERβ is more broadly expressed in metabolic tissue...