The Na+/Ca2+ Exchanger 3 Is Functionally Coupled With the NaV1.6 Voltage-Gated Channel and Promotes an Endoplasmic Reticulum Ca2+ Refilling in a Transgenic Model of Alzheimer's Disease

• Principais autores: Ilaria Piccialli (Autor), Roselia Ciccone (Autor), Agnese Secondo (Autor), Francesca Boscia (Autor), Valentina Tedeschi (Autor), Valeria de Rosa (Autor), Pasquale Cepparulo (Autor), Lucio Annunziato (Autor), Anna Pannaccione (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The remodelling of neuronal ionic homeostasis by altered channels and transporters is a critical feature of the Alzheimer's disease (AD) pathogenesis. Different reports converge on the concept that the Na+/Ca2+ exchanger (NCX), as one of the main regulators of Na+ and Ca2+ concentrations and si...