The Na+/Ca2+ Exchanger 3 Is Functionally Coupled With the NaV1.6 Voltage-Gated Channel and Promotes an Endoplasmic Reticulum Ca2+ Refilling in a Transgenic Model of Alzheimer's Disease

• Main Authors: Ilaria Piccialli (Author), Roselia Ciccone (Author), Agnese Secondo (Author), Francesca Boscia (Author), Valentina Tedeschi (Author), Valeria de Rosa (Author), Pasquale Cepparulo (Author), Lucio Annunziato (Author), Anna Pannaccione (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The remodelling of neuronal ionic homeostasis by altered channels and transporters is a critical feature of the Alzheimer's disease (AD) pathogenesis. Different reports converge on the concept that the Na+/Ca2+ exchanger (NCX), as one of the main regulators of Na+ and Ca2+ concentrations and si...