Different Mutations in a P-type ATPase Transporter in Leishmania Parasites are Associated with Cross-resistance to Two Leading Drugs by Distinct Mechanisms.

• Main Authors: Christopher Fernandez-Prada (Author), Isabel M Vincent (Author), Marie-Christine Brotherton (Author), Mathew Roberts (Author), Gaétan Roy (Author), Luis Rivas (Author), Philippe Leprohon (Author), Terry K Smith (Author), Marc Ouellette (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmania infantum is an etiological agent of the life-threatening visceral form of leishmaniasis. Liposomal amphotericin B (AmB) followed by a short administration of miltefosine (MF) is a drug combination effective for treating visceral leishmaniasis in endemic regions of India. Resistance to MF...