Epidemiology of Infant Dengue Cases Illuminates Serotype-Specificity in the Interaction between Immunity and Disease, and Changes in Transmission Dynamics.

• Main Authors: Hannah Clapham (Author), Derek A T Cummings (Author), Ananda Nisalak (Author), Siripen Kalayanarooj (Author), Butsaya Thaisomboonsuk (Author), Chonticha Klungthong (Author), Stefan Fernandez (Author), Anon Srikiatkhachorn (Author), Louis R Macareo (Author), Justin Lessler (Author), Julia Reiser (Author), In-Kyu Yoon (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Infants born to dengue immune mothers acquire maternal antibodies to dengue. These antibodies, though initially protective, decline during the first year of life to levels thought to be disease enhancing, before reaching undetectable levels. Infants have long been studied to understand th...