Estrogen and soy isoflavonoids decrease sensitivity of medulloblastoma and central nervous system primitive neuroectodermal tumor cells to chemotherapeutic cytotoxicity

• Hoofdauteurs: Scott M. Belcher (Auteur), Caleb C. Burton (Auteur), Clifford J. Cookman (Auteur), Michelle Kirby (Auteur), Gabriel L. Miranda (Auteur), Fatima O. Saeed (Auteur), Kathleen E. Wray (Auteur)
• Formaat: Boek
• Gepubliceerd in: BMC, 2017-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Background Our previous studies demonstrated that growth and migration of medulloblastoma (MB), the most common malignant brain tumor in children, are stimulated by 17β-estradiol. The growth stimulating effects of estrogens are mediated through ERβ and insulin-like growth factor 1 signaling...