Estrogen and soy isoflavonoids decrease sensitivity of medulloblastoma and central nervous system primitive neuroectodermal tumor cells to chemotherapeutic cytotoxicity

• 主要な著者: Scott M. Belcher (著者), Caleb C. Burton (著者), Clifford J. Cookman (著者), Michelle Kirby (著者), Gabriel L. Miranda (著者), Fatima O. Saeed (著者), Kathleen E. Wray (著者)
• フォーマット: 図書
• 出版事項: BMC, 2017-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Background Our previous studies demonstrated that growth and migration of medulloblastoma (MB), the most common malignant brain tumor in children, are stimulated by 17β-estradiol. The growth stimulating effects of estrogens are mediated through ERβ and insulin-like growth factor 1 signaling...