Triptolide-loaded microemulsion-based hydrogels: physical properties and percutaneous permeability

• Main Authors: Lihua Chen (Author), Xiaoting Zhao (Author), Jia Cai (Author), Yongmei Guan (Author), Sen Wang (Author), Hongning Liu (Author), Weifeng Zhu (Author), Junsong Li (Author)
• Format: Book
• Published: Elsevier, 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triptolide is a diterpenoid compound that inhibits the inflammation of rheumatoid arthritis (RA). However, the use of triptolide is limited due to its strong gastrointestinal toxicity. The purpose of this work was to develop a transdermal delivery system for triptolide to reduce this toxicity. A mic...