Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease

• Main Authors: Serena Vittorio (Author), Ilenia Adornato (Author), Rosaria Gitto (Author), Samuel Peña-Díaz (Author), Salvador Ventura (Author), Laura De Luca (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Parkinson's disease is one of the most common neurodegenerative disorders in elderly age. One of the mechanisms involved in the neurodegeneration appears related to the aggregation of the presynaptic protein alpha synuclein (α-syn) into toxic oligomers and fibrils. To date, no highly effective...