Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain

• Main Authors: Laura E. Kuil (Author), Nynke Oosterhof (Author), Samuël N. Geurts (Author), Herma C. van der Linde (Author), Erik Meijering (Author), Tjakko J. van Ham (Author)
• Format: Book
• Published: The Company of Biologists, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Microglia are brain-resident macrophages, which have specialized functions important in brain development and in disease. They colonize the brain in early embryonic stages, but few factors that drive the migration of yolk sac macrophages (YSMs) into the embryonic brain, or regulate their acquisition...