Isatin: a privileged scaffold for the design of carbonic anhydrase inhibitors

• Main Authors: Claudia Melis (Author), Rita Meleddu (Author), Andrea Angeli (Author), Simona Distinto (Author), Giulia Bianco (Author), Clemente Capasso (Author), Filippo Cottiglia (Author), Rossella Angius (Author), Claudiu T. Supuran (Author), Elias Maccioni (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have been studied and proposed as CAIs. In this study w...