Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis

• Main Authors: Man K.S. Lee (Author), Olivia D. Cooney (Author), Xuzhu Lin (Author), Shaktypreya Nadarajah (Author), Dragana Dragoljevic (Author), Kevin Huynh (Author), Danise-Ann Onda (Author), Sandra Galic (Author), Peter J. Meikle (Author), Thomas Edlund (Author), Morgan D. Fullerton (Author), Bruce E. Kemp (Author), Andrew J. Murphy (Author), Kim Loh (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Dysregulation of cholesterol metabolism in the liver and hematopoietic stem and progenitor cells (HSPCs) promotes atherosclerosis development. Previously, it has been shown that HMG-CoA-Reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathway, can be phosphorylated and inact...