Genotypic status of the TbAT1/P2 adenosine transporter of Trypanosoma brucei gambiense isolates from Northwestern Uganda following melarsoprol withdrawal.

• Main Authors: Anne J N Kazibwe (Author), Barbara Nerima (Author), Harry P de Koning (Author), Pascal Mäser (Author), Michael P Barrett (Author), Enock Matovu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>The development of arsenical and diamidine resistance in Trypanosoma brucei is associated with loss of drug uptake by the P2 purine transporter as a result of alterations in the corresponding T. brucei adenosine transporter 1 gene (TbAT1). Previously, specific TbAT1 mu...