Action of Cyclooxygenase Inhibitors and a Leukotriene Biosynthesis Inhibitor on Cisplatin-Induced Acute and Delayed Emesis in the Ferret

• Main Authors: Tasia S.W. Sam (Author), Man P. Smith (Author), Denis Riendeau (Author), Annette Robichaud (Author), John A. Smith (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin at 5 mg/kg, i.p. induced an acute (day 1) and delayed (days 2 and 3) emetic response in the ferret that was used to investigate the anti-emetic activity of the non-selective cyclooxygenase inhibitor indomethacin (3 - 30 mg/kg, i.p., three times per day) and two cyclooxygenase-2 inhibitors,...