Synthesis and Biological Evaluation of RGD-Cryptophycin Conjugates for Targeted Drug Delivery
Cryptophycins are potent tubulin polymerization inhibitors with picomolar antiproliferative potency in vitro and activity against multidrug-resistant (MDR) cancer cells. Because of neurotoxic side effects and limited efficacy in vivo, cryptophycin-52 failed as a clinical candidate in cancer treatmen...
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Main Authors: | , , , , , , , , , , , , , , |
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Format: | Book |
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MDPI AG,
2019-04-01T00:00:00Z.
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Internet
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A1234.567 |
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