Nitric oxide plays a critical role in methotrexate-induced hyperplasia of enterochromaffin cells containing 5-hydroxytryptamine in rat small intestine

• Main Authors: Yuho Takano (Author), Megumi Hirano (Author), Takuji Machida (Author), Yusuke Obara (Author), Naoya Hamaue (Author), Kana Fujita (Author), Masafumi Taniguchi (Author), Tomoko Endo (Author), Saki Shiga (Author), Maiko Machida (Author), Kenji Iizuka (Author), Masahiko Hirafuji (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The role of nitric oxide (NO) in the changes in enterochromaffin cells and ileal 5-hydroxytryptamine (5-HT) content induced by a single i.p. administration of methotrexate was investigated in rats. Methotrexate significantly increased inducible NO synthase (iNOS) mRNA and protein expressions in the...