Discovery of novel paeonol-based derivatives against skin inflammation in vitro and in vivo

• Váldodahkkit: Jing Wu (Dahkki), Ren De Zhu (Dahkki), Guo Min Cao (Dahkki), Jun Cheng Du (Dahkki), Xin Liu (Dahkki), Liang Zhuo Diao (Dahkki), Zhao Yan Zhang (Dahkki), Yang Sheng Hu (Dahkki), Xin Hua Liu (Dahkki), Jing Bo Shi (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

T-LAK-cell-originated protein kinase (TOPK), a novel member of the mitogen-activated protein kinase family, is considered an effective therapeutic target for skin inflammation. In this study, a series (A − D) of paeonol derivatives was designed and synthesised using a fragment growing approach, and...