Suppression of Matrix Metalloproteinase Production in Nasal Fibroblasts by Tranilast, an Antiallergic Agent, In Vitro

• Main Authors: Toshiyuki Shimizu (Author), Kenichi Kanai (Author), Kazuhito Asano (Author), Tadashi Hisamitsu (Author), Harumi Suzaki (Author)
• Format: Book
• Published: Hindawi Limited, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Allergic rhinitis is an inflammatory disease characterized by nasal wall remodeling with intense infiltration of eosinophils and mast cells/basophils. Matrix metalloproteinases (MMPs), MMP-2 and MMP-9, are the major proteolytic enzymes that induce airway remodeling. These enzymes are also important...