Safety and efficacy of paromomycin/miltefosine/liposomal amphotericin B combinations for the treatment of post-kala-azar dermal leishmaniasis in Sudan: A phase II, open label, randomized, parallel arm study.

• Main Authors: Brima Musa Younis (Author), Ahmed Mudawi Musa (Author), Séverine Monnerat (Author), Mohammed Abdelrahim Saeed (Author), Eltahir Awad Gasim Khalil (Author), Anas Elbashir Ahmed (Author), Mujahid Ahmed Ali (Author), Ali Noureldin (Author), Gina Muthoni Ouattara (Author), Godfrey M Nyakaya (Author), Samuel Teshome (Author), Truphosa Omollo (Author), Michael Ochieng (Author), Thaddaeus Egondi (Author), Mildred Mmbone (Author), Wan-Yu Chu (Author), Thomas P C Dorlo (Author), Eduard E Zijlstra (Author), Monique Wasunna (Author), Jorge Alvar (Author), Fabiana Alves (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Treatment for post-kala-azar dermal leishmaniasis (PKDL) in Sudan is currently recommended only for patients with persistent or severe disease, mainly because of the limitations of current therapies, namely toxicity and long hospitalization. We assessed the safety and...