Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats

• Main Authors: Prem Kumar Govindappa (Author), Darukeshwara Joladarashi (Author), Raghavendra Lakshmana Shetty Hallur (Author), Jagadeesh S. Sanganal (Author), Ayyalasomayajula Ratna Phani (Author)
• Format: Book
• Published: Elsevier, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The 6-mercaptopurine (6-MP) is an effective immunosuppressant and anti-cancer drug. However, the usage of 6-MP is limited due to its well-known side effects, such as myelotoxicity and hepato-renal toxicity. To curtail the potential toxic effects, we have used chitosan as a natural biodeg...