Pharmacological Vitamin C Treatment Impedes the Growth of Endogenous Glutamine-Dependent Cancers by Targeting Glutamine Synthetase

• Main Authors: Yali Long (Author), Jia Qiu (Author), Bing Zhang (Author), Peng He (Author), Xinchong Shi (Author), Qiao He (Author), Zhifeng Chen (Author), Wanqing Shen (Author), Zhoulei Li (Author), Xiangsong Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Glutamine synthetase (GS) is the only currently known enzyme responsible for synthesizing endogenous glutamine (Gln). GS exerts a critical role in the oncogenesis of endogenous Gln-dependent cancers, making it an attractive target for anti-tumor therapies. A mixed-function oxidation system...