The Wnt signaling pathway in tumorigenesis, pharmacological targets, and drug development for cancer therapy

• Main Authors: Zhuo Wang (Author), Tingting Zhao (Author), Shihui Zhang (Author), Junkai Wang (Author), Yunyun Chen (Author), Hongzhou Zhao (Author), Yaxin Yang (Author), Songlin Shi (Author), Qiang Chen (Author), Kuancan Liu (Author)
• Format: Book
• Published: BMC, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Wnt signaling was initially recognized to be vital for tissue development and homeostasis maintenance. Further studies revealed that this pathway is also important for tumorigenesis and progression. Abnormal expression of signaling components through gene mutation or epigenetic regulation i...