CNS Penetration of Cyclophosphamide and Metabolites in Mice Bearing Group 3 Medulloblastoma and Non-Tumor Bearing Mice

• Prif Awduron: Olivia Campagne (Awdur), Abigail Davis (Awdur), Bo Zhong (Awdur), Sreenath Nair (Awdur), Victoria Haberman (Awdur), Yogesh T. Patel (Awdur), Laura Janke (Awdur), Martine F. Roussel (Awdur), Clinton Stewart (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

PURPOSE: Cyclophosphamide is widely used to treat children with medulloblastoma; however, little is known about its brain penetration. We performed cerebral microdialysis to characterize the brain penetration of cyclophosphamide (130 mg/kg, IP) and its metabolites [4-hydroxy-cyclophosphamide (4OH-CT...