CNS Penetration of Cyclophosphamide and Metabolites in Mice Bearing Group 3 Medulloblastoma and Non-Tumor Bearing Mice

• Main Authors: Olivia Campagne (Author), Abigail Davis (Author), Bo Zhong (Author), Sreenath Nair (Author), Victoria Haberman (Author), Yogesh T. Patel (Author), Laura Janke (Author), Martine F. Roussel (Author), Clinton Stewart (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: Cyclophosphamide is widely used to treat children with medulloblastoma; however, little is known about its brain penetration. We performed cerebral microdialysis to characterize the brain penetration of cyclophosphamide (130 mg/kg, IP) and its metabolites [4-hydroxy-cyclophosphamide (4OH-CT...