Insulin Fused to Apolipoprotein A-I Reduces Body Weight and Steatosis in DB/DB Mice

• Main Authors: Nuria Ardaiz (Author), Celia Gomar (Author), Marcos Vasquez (Author), Shirley Tenesaca (Author), Myriam Fernandez-Sendin (Author), Claudia Augusta Di Trani (Author), Virginia Belsué (Author), Javier Escalada (Author), Ulrich Werner (Author), Norbert Tennagels (Author), Pedro Berraondo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Targeting long-lasting insulins to the liver may improve metabolic alterations that are not corrected with current insulin replacement therapies. However, insulin is only able to promote lipogenesis but not to block gluconeogenesis in the insulin-resistant liver, exacerbating liver steat...