Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production

• Main Authors: Ying Shiuan Lee (Author), Filipe De Vadder (Author), Valentina Tremaroli (Author), Anita Wichmann (Author), Gilles Mithieux (Author), Fredrik Bäckhed (Author)
• Format: Book
• Published: Elsevier, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin-like peptide 5 (INSL5) is a recently identified gut hormone that is produced predominantly by L-cells in the colon, but its function is unclear. We have previously shown that colonic expression of the gene for the L-cell hormone GLP-1 is high in mice that lack a microbiota and thu...