Combination Treatment With Inhibitors of ERK and Autophagy Enhances Antitumor Activity of Betulinic Acid in Non-small-Cell Lung Cancer In Vivo and In Vitro

• Main Authors: Chao-Yue Sun (Author), Di Cao (Author), Qian-Nan Ren (Author), Shan-Shan Zhang (Author), Ning-Ning Zhou (Author), Shi-Juan Mai (Author), Bing Feng (Author), Hui-Yun Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant activation of the Ras-ERK signaling pathway drives many important cancer phenotypes, and several inhibitors targeting such pathways are under investigation and/or approved by the FDA as single- or multi-agent therapy for patients with melanoma and non-small-cell lung cancer (NSCLC). Here, w...