Genetic variants in LGALS3 are related to lower galectin-3 serum levels and clinical outcomes in systemic sclerosis patients: A case-control study

• Main Authors: Eudes Gustavo Constantino Cunha (Author), Camilla Albertina Dantas de Lima (Author), Kamila de Melo Vilar (Author), Marcelo Francisco de Nóbrega (Author), Anderson Rodrigues de Almeida (Author), Michelly Cristiny Pereira (Author), Andréa Tavares Dantas (Author), Rafaela Silva Guimarães Gonçalves (Author), Moacyr Jesus Barreto de Melo Rêgo (Author), Angela Luzia Branco Pinto Duarte (Author), Maira Galdino da Rocha Pitta (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction Systemic sclerosis (SSc) is a rare complex disease characterized by vascular damage, autoimmunity, and extensive skin and internal organs fibrosis. Galectin-3 (Gal-3) is encoded by gene LGALS3 (Lectin, Galactoside-Binding, Soluble, 3; 14q22.3) and it has been reported to play a central...