MUC16 stimulates neutrophils to an inflammatory and immunosuppressive phenotype in ovarian cancer

• Main Authors: Yuliang Wu (Author), Qi Liu (Author), Yan Xie (Author), Jihui Zhu (Author), Sai Zhang (Author), Yao Ge (Author), Jing Guo (Author), Ning Luo (Author), Wei Huang (Author), Runping Xu (Author), Shupeng Liu (Author), Zhongping Cheng (Author)
• Format: Book
• Published: BMC, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background MUC16 (CA125) is a commonly used tumor marker for ovarian cancer screening and reported to be an immunosuppressive factor by acting on the sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on the surface of natural killer cells (NK cells), B cells, and monocytes. Howeve...