Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel

• Main Authors: L.A. Lefol (Author), P. Bawuah (Author), J.A. Zeitler (Author), J. Verin (Author), F. Danede (Author), J.F. Willart (Author), F. Siepmann (Author), J. Siepmann (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to evaluate and better understand the potential impact that a layer of surrounding hydrogel (mimicking living tissue) can have on the drug release from PLGA microparticles. Ibuprofen-loaded microparticles were prepared with an emulsion solvent extraction/evaporation method. The drug...