Molecular glues modulate protein functions by inducing protein aggregation: A promising therapeutic strategy of small molecules for disease treatment

• Main Authors: Hongyu Wu (Author), Hong Yao (Author), Chen He (Author), Yilin Jia (Author), Zheying Zhu (Author), Shengtao Xu (Author), Dahong Li (Author), Jinyi Xu (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Molecular glues can specifically induce aggregation between two or more proteins to modulate biological functions. In recent years, molecular glues have been widely used as protein degraders. In addition, however, molecular glues play a variety of vital roles, such as complex stabilization, interact...