Factor VIII inhibitor development in Egyptian hemophilia patients: does intron 22 inversion mutation play a role?

• Main Authors: Laila M. Sherief (Author), Osama A. Gaber (Author), Hala Mosaad Youssef (Author), Hanan S. Sherbiny (Author), Wesam a Mokhtar (Author), Asmaa A. A. Ali (Author), Naglaa M. Kamal (Author), Yehia H. Abdel Maksoud (Author)
• Format: Book
• Published: BMC, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Hemophilia A (HA) is an X-linked recessive bleeding disorder characterized by qualitative and quantitative deficiency of factor VIII (FVIII). The development of inhibitor antibodies against FVIII is the most challenging complication of treatment. Mutations in the FVIII gene is on...