Brief research report: Repurposing pentoxifylline to treat intense acute swimming-Induced delayed-onset muscle soreness in mice: Targeting peripheral and spinal cord nociceptive mechanisms

• Main Authors: Sergio M. Borghi (Author), Tiago H. Zaninelli (Author), Telma Saraiva-Santos (Author), Mariana M. Bertozzi (Author), Renato D. R. Cardoso (Author), Thacyana T. Carvalho (Author), Camila R. Ferraz (Author), Doumit Camilios-Neto (Author), Fernando Q. Cunha (Author), Thiago M. Cunha (Author), Felipe A. Pinho-Ribeiro (Author), Rubia Casagrande (Author), Waldiceu A. Verri (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we pursue determining the effect of pentoxifylline (Ptx) in delayed-onset muscle soreness (DOMS) triggered by exposing untrained mice to intense acute swimming exercise (120 min), which, to our knowledge, has not been investigated. Ptx treatment (1.5, 4.5, and 13.5 mg/kg; i.p., 30 min...