The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells

• Main Authors: Junxia Wang (Author), Minghua Chen (Author), Mengyan Wang (Author), Wenxia Zhao (Author), Conghui Zhang (Author), Xiujun Liu (Author), Meilian Cai (Author), Yuhan Qiu (Author), Tianshu Zhang (Author), Huimin Zhou (Author), Wuli Zhao (Author), Shuyi Si (Author), Rongguang Shao (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic adenocarcinoma (PAAD) is one of the most lethal malignancies. Although gemcitabine (GEM) is a standard treatment for PAAD, resistance limits its application and therapy. Secoemestrin C (Sec C) is a natural compound from the endophytic fungus Emericella, and its anticancer activity has not...